Explaining Influences on Career \u27Choice\u27 in Comparative Perspective

This study explores the influences on career choices of the MBA students from three countries at micro-individual, meso-institutional and relational and macro-structural levels, questioning the apparent dominance of ‘free choice’ in the context of persistent forms of structural constraints in career markets. The paper takes a critical perspective on career ‘choice’, acknowledging the contested nature of ‘choice’ and identifying career as a product of socially and historically situated choices which are negotiated through structural constraints The central hypothesis of the study is that ‘it is more likely for the MBA students to report micro-agentic or meso-instutional and relational rather than macro-structural conditions as key influences on their career choices’. The study draws on the findings of a cross-national survey involving Britain, Israel, and Turkey, using the career choice dimensions designed by Özbilgin and Healy (2003). Findings show that MBA students consider the impact of structural conditions as less significant on their career choices than their own human capital and capacity to make free choices. The study provides an understanding of the main cross-national diversities and similarities in reporting of influences on career ‘choice’, and brings to bare interesting theoretical and methodological insights

Histological features in abdominal wall endometriosis

Endometriosis is localization of endometrial tissue out of endometrium and myometrium. Location on peritoneum and scar tissue associated with abdominal incision called as abdominal wall endometriosis (AWE). Abdominal wall endometriosis is a rare lesion affection under 1% of effected patients. However, due to increase in laparoscopy, hysterectomy and cesarean section procedurs, the AWE cases are increasing. In this study we aim to analyse AWE rates and evaluate their histologic properties. Endometriosis cases between 2010-2015 were included in study. These cases were evaluated according to localization and out of these 23 cases were revealed as AWE, and in 15 of 23 cases histologic specimens can reach. 317 cases with endometriosis were revealed and 23 (7.2%) were identified as AWE. The mean age was 35±5 (29-45). In 11 (47.8%) cases AWE was developed on scar tissue which have a history of cesarean section procedurs in a mean 3.4 year before. In 10 (66%) cases tubal (ciliary) metaplasia, in 3 (20%) cases hobnail metaplasia and in one case (7%) atypia and mitosis were observed as glandular changes. In 11 (73%) cases myxoid changes, 3 (20%) signet ring-like cells-like changes, 2 (13%) atypical myocytes with giant cells, in one (7%) case thick walled vessels resemble spiral arteries of endometrium and in one case (7%) decidual changes were observed as stromal changes. In this study we highlight the high prevalence of AWE compare to literature. Besides, the wide spectrum of stromal and glandular metaplastic changes could be challenging in proper diagnosis. AWE should keep in mind in the differential diagnosis of lesions in this localization. [Med-Science 2018; 7(2.000): 398-401

Explaining Influences on Career 'Choice' in Comparative Perspective

Mustafa Özbilgin is a Senior Lecturer in Business Management at Queen Mary, University of London. His research is in the field of comparative and cross-national employment studies, with a specific focus on issues of diversity, equality and fairness. He spent Fall 2004 as a Cornell-ILR Visiting Fellow. Lisa Nishii served as faculty sponsor.This study explores the influences on career choices of the MBA students from three countries at micro-individual, meso-institutional and relational and macro-structural levels, questioning the apparent dominance of ‘free choice’ in the context of persistent forms of structural constraints in career markets. The paper takes a critical perspective on career ‘choice’, acknowledging the contested nature of ‘choice’ and identifying career as a product of socially and historically situated choices which are negotiated through structural constraints The central hypothesis of the study is that ‘it is more likely for the MBA students to report micro-agentic or meso-instutional and relational rather than macro-structural conditions as key influences on their career choices’. The study draws on the findings of a cross-national survey involving Britain, Israel, and Turkey, using the career choice dimensions designed by Özbilgin and Healy (2003). Findings show that MBA students consider the impact of structural conditions as less significant on their career choices than their own human capital and capacity to make free choices. The study provides an understanding of the main cross-national diversities and similarities in reporting of influences on career ‘choice’, and brings to bare interesting theoretical and methodological insights.Ozbilgin_WP_careerchoice.PDF: 13760 downloads, before Oct. 1, 2020

Interobserver reproducibility of tumor-infiltrating lymphocyte evaluations in breast cancer

Aim: Tumor-infiltrating lymphocytes (TILs) have a prognostic value in breast cancer (BC); however, because of the lack of standard evaluation methods, we aimed to assess the interobserver agreement of stromal TILs (sTILs) and intratumoral TILs (iTILs) as well as the effect of hot spot areas and molecular subtyping on the overall agreement. Methods: The study consisted of 121 haematoxylin and eosin (H and E)-stained slides of invasive BC samples obtained from the pathology archives. The TIL assessment was based on the International TIL Working Group recommendations for the percentage of sTILs and was conducted by four pathologists. The percentage of iTILs, the number of lymphocytes in hot spot areas (iTILs-HS), and the overall interobserver agreement for the molecular subtypes were evaluated. The interclass correlation coefficient (ICC) was used to assess interobserver agreement among the four pathologists. Results: The ICC score among the observers for the sTIL percentages was 0.74, and the individual ICC values for each molecular subtype were 0.55, 0.88, and 0.79 for luminal, HER2-positive, and triple-negative tumors, respectively. The compliance value for the iTILs was 0.29 (95% confidence interval (CI) = 0.06–0.48], whereas the compliance value for the iTILs-HS was 0.63 (95% CI = 0.49–0.71). The compliance values for the iTILs-HS subtypes were 0.72, 0.43, and 0.55 for luminal, HER2-positive, and triple-negative tumors, respectively. Conclusion: The IWTILG recommendations are reproducible and reliable. The interobserver agreement of the sTIL percentages was considerably higher for the triple-negative and HER2-positive cases than the luminal cases, whereas the interobserver agreement for the assessment of iTILs-HS in tumors was higher for the luminal subtype

Interobserver reproducibility of tumor-infiltrating lymphocyte evaluations in breast cancer

Aim: Tumor-infiltrating lymphocytes (TILs) have a prognostic value in breast cancer (BC); however, because of the lack of standard evaluation methods, we aimed to assess the interobserver agreement of stromal TILs (sTILs) and intratumoral TILs (iTILs) as well as the effect of hot spot areas and molecular subtyping on the overall agreement. Methods: The study consisted of 121 haematoxylin and eosin (H and E)-stained slides of invasive BC samples obtained from the pathology archives. The TIL assessment was based on the International TIL Working Group recommendations for the percentage of sTILs and was conducted by four pathologists. The percentage of iTILs, the number of lymphocytes in hot spot areas (iTILs-HS), and the overall interobserver agreement for the molecular subtypes were evaluated. The interclass correlation coefficient (ICC) was used to assess interobserver agreement among the four pathologists. Results: The ICC score among the observers for the sTIL percentages was 0.74, and the individual ICC values for each molecular subtype were 0.55, 0.88, and 0.79 for luminal, HER2-positive, and triple-negative tumors, respectively. The compliance value for the iTILs was 0.29 (95% confidence interval (CI) = 0.06-0.48], whereas the compliance value for the iTILs-HS was 0.63 (95% CI = 0.49-0.71). The compliance values for the iTILs-HS subtypes were 0.72, 0.43, and 0.55 for luminal, HER2-positive, and triple-negative tumors, respectively. Conclusion: The IWTILG recommendations are reproducible and reliable. The interobserver agreement of the sTIL percentages was considerably higher for the triple-negative and HER2-positive cases than the luminal cases, whereas the interobserver agreement for the assessment of iTILs-HS in tumors was higher for the luminal subtype

A Rare Tumor that Mimicked Metastasis in a Patient with Breast Cancer: Epithelioid Hemangioendothelioma

WOS: 000382991600007PubMed ID: 28331739A woman aged 50 years was diagnosed as having an invasive ductal carcinoma in the right breast and ductal carcinoma in situ in the left breast and underwent bilateral mastectomy eight years ago. A mass was identified during follow-up in positron-emission tomography (PET) image in the left infraclavicular region, indicating metastasis. Histopathologic examination showed a mass of 1.9 x 1 x 0.7 cm in dimensions characterized by spindle or round nuclei cells that formed island or cords in hyaline and myxoid ground and intracytoplasmic vacuoles containing erythrocytes. In the immunohistochemical analysis, tumor cells were widespread with diffuse positivity with CD34 and vimentin. These findings redirected us from a diagnosis of metastatic carcinoma to epithelioid hemangioendothelioma, a rare tumor of intermediate vascular tumor groups. In this respect, confirmation through biopsy from considered cases of metastasis is important in making a definite pathologic differential diagnosis

Convergence and Divergence of Influences on Career Choice : A Comparative Analysis of Influences on Career Choices of MBA Students in China, Ghana, Greece, Israel, Korea, North Cyprus, Turkey and UK

Non peer reviewe

Fast-Dissolving, Prolonged Release, and Antibacterial Cyclodextrin/Limonene-Inclusion Complex Nanofibrous Webs via Polymer-Free Electrospinning

We have proposed a new strategy for preparing free-standing nanofibrous webs from an inclusion complex (IC) of a well-known flavor/fragrance compound (limonene) with three modified cyclodextrins (HP beta CD, M beta CD, and HP gamma CD) via electrospinning (CD/limonene-IC-NFs) without using a polymeric matrix. The experimental and computational modeling studies proved that the stoichiometry of the complexes was 1:1 for CD/limonene systems. M beta CD/limonene-IC-NF released much more limonene at 37, 50, and 75 degrees C than HP beta CD/limonene-IC-NF and HP gamma CD/limonene-IC-NF because of the greater amount of preserved limonene. Moreover, M beta CD/limonene-IC-NF has released only 25\% (w/w) of its limonene, whereas HP beta CD/limonene-IC-NF and HP gamma CD/limonene-IC-NF released 51 and 88\% (w/w) of their limonene in 100 days, respectively. CD/limonene-IC-NFs exhibited high antibacterial activity against E. coli and S. aureus. The water solubility of limonene increased significantly and CD/limonene-IC-NFs were dissolved in water in a few seconds. In brief, CD/limonene-IC-NFs with fast dissolving character enhanced the thermal stability and prolonged the shelf life along with antibacterial properties could be quite applicable in food and oral care applications